Keep track of Carefully (3)pentobarbital will lessen the extent or influence of diazepam intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Sturdy or reasonable CYP3A4 inducers may perhaps maximize amount of diazepam elimination; hence, efficacy of diazepam may be diminished.fentanyl transmucosal and pentobarbit